Co-invented first surfactant and oil systems enabling PCR and cell-based assays in droplets

Directed development of synthesis, QC, and manufacturing of first reagents for droplet-based tools (now ubiquitous and basis for numerous companies and products)

Co-invented approaches to produce and "barcode" droplet libraries

Contributed to earliest technical feasibility for droplet digital PCR (e.g., microfluidics, fluorescence detection, statistics)

Co-invented approach to construct 3-dimensional microfluidic circuits from novel photopolymers

Led development and launch of first thermoplastic microfluidic consumable (partnership with Sony DADC – now Stratec Consumables)

Directed implementation of new product development process and quality system

Guided product development and manufacturing of HIVE through team construction, technical oversight, and project management

Oversaw workflow development combining CTC enrichment technology with RNA sequencing analysis

Coordinated KOL study to validate liver cancer early detection liquid biopsy assay (deployed technology and processed >200 patient blood samples in ~6 months)

Led global development effort for Clonal Amplification Subsystem (productizing emulsion PCR technology)

Led high-urgency taskforce (in last months before planned launch) that succeeded to root-cause and solve a critical flowcell reliability issue

Contributed to core product development project (microfluidics development and integration, data analysis tools)

Coordinated multi-year collaboration for detection of mutations from liquid and solid biopsies for cancer prognosis, therapy selection, and recurrence monitoring

Contributed to core product development project (surfactant-oil reagents and microfluidics integration)

Collaborated with Manufacturing teams to co-develop tools for production and QC of emulsion library products